Anti-HMGCR Rabbit Polyclonal Antibody VWR

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Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. HMGCR protein expression summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechani sm mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. HMGCR is associated with 4 reactions in 3 different subsystems: Boundary, Cytosol, Endoplasmic reticulum, Extracellular, Golgi apparatus, Inner mitochondria, Lysosome, Mitochondria, Nucleus, Peroxisome. Provided by metabolicatlas.org: Pathway / Subsystem Compartments # proteins # metabolites # reactions for this protein; Transport reactions The HMGCR gene encodes HMG-CoA reductase, a protein best known as being the target for drugs designed to reduce cholesterol levels and thereby reduce the risk for heart disease.

Hmgcr gene

GENCODE basic,

APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene.

APPRIS P1, Hmgcr-209 Implications. This is the first study linking pig 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression levels with carcass and meat quality traits.This gene, which codes for the limiting enzyme in the de novo synthesis of cholesterol, regulates plasma lipid levels and cholesterol uptake in humans. 2021-01-22 · Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease. Xueyan Zhao, Jiawen Li, Xiaofang Tang, Ru Liu, Jingjing Xu, Lianjun Xu, Lin Jiang, Keyong Huang, Jian Tian, Xinxing Feng, Yajie Wu, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, 2011-01-31 · Hmgcr endogenous gene expression studies: possible mechanisms for differential transcript abundance. Tissue distribution pattern of the Hmgcr gene showed a high level of expression in the liver .

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38, HMGCR rs12916 and cancer risk was analysed by Cox regression with attained age as time-scale, and the SNP as a continuous 0,1,2 (CC, CT, TT) variable. KJ891361 - Synthetic construct Homo sapiens clone ccsbBroadEn_00755 HMGCR gene, encodes complete protein. AK312437 - Homo sapiens cDNA, FLJ92784, highly similar to Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), mRNA.

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Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. HMG Coenzyme A reductase (Hmgcr) encodes the rate-controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required during heart tube formation, molting regulation and primordial germ cell migration.

1 RefSeq (NM) Transcript Type Coding Product Type Stealth siRNA Availability. Made to Order. Catalog # 1320001 20 nmol; Price: See in cart Your Price: Online offer: Check your price › Add To Cart Add to Array HMGCR Gene Expression in HepG2 Cell Lines (Sarang Burung Wale t (EBN) Berdos Tinggi Meningkatkan LDL-R melalui Perencatan Gen HMGCR dalam Sel HepG2) MOHD NOOR AKMAL, ABDUL RAZAK INTAN-SHAMEHA, ROZAIHAN MANSOR, AINI IDERIS, ABDUL RAHMAN OMAR, JALILA ABU, MOHD FAIZ IDRIS & MOKRISH AJAT* 2012-03-20 HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. (52) Additional Compounds for HMGCR Gene - From: Novoseek, HMDB, and Tocris (3S)-3-Hydroxy-3-methylglutaryl-coenzyme A (S)-3-Hydroxy-3-methylglutaryl-coenzyme A 3-Hydroxy-3-methylglutaryl-CoA HMG-CoA HMG-coenzyme A HMGCR gene variation is associated with multiple lipid/lipoprotein traits, especially with triglyceride. The impact of the genetic variance is modest and differs greatly among ethnicities. Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. HMGCR protein expression summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechani sm mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.
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Addgene Alerts Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description HMG Coenzyme A reductase Also known as Dmel_CG10367, BcDNA:LD15354, CG10367, Clb, DmHMG-CoAr, Dmel\CG10367, HMGCR, HMGCR HMGCR gene expression in animals with extreme lipid metabolism and its relationship with phenotypic measures. Figure 2b presents the comparison of HMGCR muscle and liver expression levels in two groups of Duroc pigs corresponding to the most extreme animals for 13 traits related to growth, HMGCR gene product.

Provided by metabolicatlas.org: Pathway / Subsystem Compartments # proteins # metabolites # reactions for this protein; Transport reactions The HMGCR gene encodes HMG-CoA reductase, a protein best known as being the target for drugs designed to reduce cholesterol levels and thereby reduce the risk for heart disease.
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The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers.

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GENCODE basic,

APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene.

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We discovered that Hmgcr regulates carbohydrate-dependent Few viruses have affected humanity as much as IAV We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and Few viruses have affected humanity as much as IAV We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and Sornaa First Name Personality & Popularity Foto. USH2A Gene Editing Using the CRISPR System: Molecular Foto. Gå till.

cN1A-antikroppar. Jo-1, PL-7, cleft 1 candidate gene 1 protein homolog OS=Gallus gallus GN=OFCC1 PE=2 SV=1 Uncharacterized protein OS=Gallus gallus GN=HMGCR PE=2 SV=1 Caroline medverkar i flera internationella samarbetsprojekt som the Genetic A functional polymorphism in the HMGCR promoter affects transcriptional activity L-G, Nyberg, L. Influence of COMT gene polymorphism on fMRI-assessed S. A functional polymorphism in the HMGCR promoter affects transcriptional activity Genes down-regulated ≥2.5 fold in the cerebellum of male pups from mothers having FA supplementation during gestation at 20 mg/kg in Hmgcr, -7.90. 2467 individuals in the general population-based EpiHealth. study [13]. Using summary data from large GWASs for dia-. betes and related 113, 319711, E230029C05Rik, RIKEN cDNA E230029C05 gene, ncRNA, 4.37E-05 662, 15357, Hmgcr, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Target genes.